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Increased oxidation of acetaminophen after starvation is also due to induction of CYP450 isoforms that start to convert more APAP to the toxic metabolite NAPQI [43]

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Particularly insightful mechanistic evidence comes from a medaka fish NAFLD model, where metabolomic analysis revealed that L-carnitine not only reduced hepatic lipid deposition but also significantly elevated hepatic -oxidation end products (acetyl-CoA and ATP) while upregulating antioxidant enzyme superoxide dismutase 2 (SOD2) (35)